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A Case of Severe MAGIC Syndrome Treated Successfully With the Tumor Necrosis Factor-Alpha Inhibitor Infliximab

Geissal, Erik D. MD; Wernick, Richard MD

JCR: Journal of Clinical Rheumatology: June 2010 - Volume 16 - Issue 4 - p 185-187
doi: 10.1097/RHU.0b013e3181dfce16
Case Report

We report a patient with an overlap of relapsing polychondritis and Behcet disease whose cartilaginous inflammation and genital lesions were refractory to corticosteroids and immunosuppressants, but fully remitted with the tumor necrosis factor-alpha inhibitor, infliximab. We believe this case represents the first report of a response to a tumor necrosis factor inhibitor in a patient with mouth and genital ulcerations with inflamed cartilage syndrome.

This patient had oral and genital ulcers along with nasal and ear chondritis and scleritis. All has been resolved on treatment with infliximab.

From the Department of Medical Education, Providence Portland Medical Center, Portland, OR.

Correspondence: Richard Wernick, MD, Department of Medical Education, Providence Portland Medical Center, 5050 NE Hoyt Street, Suite 540, Portland, OR 97213. E-mail:

© 2010 Lippincott Williams & Wilkins, Inc.