Case ReportUnilateral Eosinophilic Fasciitis: An Under-Recognized Subtype?Daniel, Rodney S. MD*; Lavery, Sarah MD†; Maize, John C. Jr MD‡; Brown, Alan N. MD*; Bolster, Marcy B. MD*Author Information From the *Division of Rheumatology, Medical University of South Carolina, Charleston, South Carolina; †Private Practice, Crestview Hills, Kentucky; and ‡Dermpath Diagnostics Maize Center for Dermatopathology Mt. Pleasant, South Carolina. This case report has not previously been published or presented in another form (eg, published as an abstract or presented at a meeting). We do not have actual, potential, or apparent conflicts of interest. There has been no financial support for this case report. Correspondence: Rodney S. Daniel, MD, Medical University of South Carolina, Division of Rheumatology, Charleston, SC. E-mail: email@example.com JCR: Journal of Clinical Rheumatology: August 2009 - Volume 15 - Issue 5 - p 247-249 doi: 10.1097/RHU.0b013e3181b0fca6 Buy Metrics AbstractIn Brief Symmetric skin thickening of the limbs with deep fascial inflammation is the hallmark of eosinophilic fasciitis. We describe a woman who presented with unilateral progressive skin thickening. Examination of a full thickness skin biopsy revealed an inflammatory process and fascial changes consistent with eosinophilic fasciitis. In contrast to other scleroderma mimics, eosinophilic fasciitis generally responds rapidly to glucocorticoid therapy. It is possible that unilateral eosinophilic fasciitis is under-recognized and can easily be misdiagnosed as another scleroderma variant if a full thickness biopsy is not reviewed by a dermatopathologist. Recognition of this subtype of eosinophilic fasciitis is important given the profound differences in prognosis of eosinophilic fasciitis and other scleroderma variants. This 26 year old woman developed unilateral eosinophilic fasciitis shortly after a laceration to that hand. She responded well to therapy will prednosone. © 2009 Lippincott Williams & Wilkins, Inc.