Case ReportAntiphospholipid Syndrome in a 21-Year-Old with Klinefelter SyndromeMount, George R. MD; Roebuck, Jonathan D. MDAuthor Information From the Rheumatology Service, Walter Reed Army Medical Center, NW, Washington, DC. The opinions or assertions contained here are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. The authors of this manuscript report no conflicts of interest. Correspondence: Dr. George Mount, MD, Walter Reed Army Medical Center, 6900 Georgia Ave., NW, Washington, DC 20307. E-mail: [email protected]. JCR: Journal of Clinical Rheumatology: January 2009 - Volume 15 - Issue 1 - p 27-28 doi: 10.1097/RHU.0b013e31817de084 Buy Metrics AbstractIn Brief We describe a patient with Klinefelter syndrome presenting with recurrent arterial thromboses secondary to the antiphospholipid syndrome. Previous case reports noted association of Klinefelter syndrome with systemic lupus erythematosus including some cases with antiphospholipid syndrome. Clinicians should consider autoimmune processes, including the antiphospholipid syndrome, when patients with Klinefelter syndrome present with recurrent thrombosis or additional features of a systemic autoimmune disorder. This man had recurrent venous thromboses and APL but no evidence of systemic lupus or other associated autoimmune disease. © 2009 Lippincott Williams & Wilkins, Inc.