Basic ScienceBasic Science for the Clinician 41 Tails of Cytokine Receptor Activation and Control: JAKs, STATs, PIASs, and SOCSsSigal, Leonard H. MD, FACP, FACRAuthor Information From the Pharmaceutical Research Institute, Bristol-Myers Squibb and the Division of Rheumatology and Connective Tissue Research, Departments of Medicine, Pediatrics and Molecular Genetics & Microbiology, University of Medicine & Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey. Reprints: Leonard H. Sigal, MD, Pharmaceutical Research Institute/Bristol-Myers Squibb, J.3100, P.O. Box 4000, Princeton, NJ 08543-4000. E-mail: [email protected] JCR: Journal of Clinical Rheumatology: December 2006 - Volume 12 - Issue 6 - p 315-319 doi: 10.1097/01.rhu.0000249809.10279.68 Buy Metrics AbstractIn Brief We now have an emerging sense of the details of how cytokines deliver their signals through the specific receptors to which they bind and the means by which these messages are modulated. Using common mechanisms, many of which have been described in past articles in this series, tight controls are maintained over this signaling. A better understanding of the molecular details of these pathways has provided insights into the pathogenesis of some malignancies and immunodeficiency syndromes and may ultimately yield therapeutic agents of use in the treatment of inflammatory and autoimmune diseases. These important pathways in cytokine signaling offer targets for therapy. © 2006 Lippincott Williams & Wilkins, Inc.