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Neutrophilic Myositis: An Extra-Intestinal Manifestation of Ulcerative Colitis

Qureshi, Jazibeh A.; Staugaitis, Susan M.; Calabrese, Leonard H.

JCR: Journal of Clinical Rheumatology: April 2002 - Volume 8 - Issue 2 - p 85-88
Case Reports

Myositis of the skeletal muscle is rarely seen as an extraintestinal manifestation of inflammatory bowel disease. We report a case of a 36-year-old man with ulcerative colitis who developed 3 episodes of steroid responsive myositis in a 4-month period. He presented with a blistering rash followed by pain and massive swelling in the right shoulder and lower extremities, with marked elevation in muscle enzymes. Diagnosis of myositis was made after a muscle biopsy, which showed neutrophilic infiltrate in the deep subcutaneous tissue and skeletal muscle. Review of the literature indicates only a few cases of myositis associated with ulcerative colitis, most of them during an acute exacerbation of the disease. However, the present patient had his first episode when the ulcerative colitis was in remission. Myositis in ulcerative colitis may present atypically, in particular mimicking pyomyositis. Clinicians should be aware of this unusual steroid-sensitive complication.

Department of Rheumatic and Immunologic Disease (JAQ, LHC) and Departments of Neurosciences and Anatomic Pathology (SMS).

Address correspondence to: Leonard Calabrese, DO, Vice Chairman, Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.