In their article, Diagnostic Accuracy of the Proton Pump Inhibitor Test in Gastroesophageal Reflux Disease and Noncardiac Chest Pain
, Ghoneim et al., reassess the accuracy of the PPI test in GERD and noncardiac chest pain using systematic review and metanalysis. The results demonstrate that the PPI test is sensitive but with suboptimal specificity for detecting GERD in patients with typical symptoms. The PPI test demonstrated moderate-to-high accuracy in diagnosing GERD-related NCCP. While the PPI test performed slightly better in NERD, the overall diagnostic accuracy was comparable in both NERD and erosive esophagitis. This study further cement the value of the PPI test in GERD, specifically in patients presenting with typical symptoms and without alarm manifestation.
Ronnie Fass, MD