Original Article: PDF OnlyInfantile Hypertrophie Pyloric Stenosis—Congenital or Acquired?*Markowitz, Richard I. M.D.; Wolfson, Barbara J. M.D.; Huff, Dale S. M.D.; Capitanio, Marie A. M.D.Author Information From the Departments of Radiology (RIM, BJW, MAC), and Pathology (DSH), Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania, and Temple University School of Medicine, Philadelphia, Pennsylvania. * Presented at the Annual Meeting of the Radiologic Society of North America, Atlanta, Georgia, November 29, 1979. Write for reprints to: Richard I. Markowitz, M.D., Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510. Journal of Clinical Gastroenterology: February 1982 - Volume 4 - Issue 1 - p 39-44 Buy Abstract Three cases of IHPS are presented in which an ulcer or a local irritant was an associated factor. Mucosal irritation leading to pyloric and antral spasm and then to muscular hypertrophy and obstruction is a possible explanation for the pathogenesis of the disease observed in these three infants. A review of the literature also leads us to conclude that IHPS is an acquired disease with a genetic or familial predisposition. Peptic ulcer may be an etiologic factor in some instances; however, the presence of a small ulcer is difficult to demonstrate in the majority of clinical cases. © Lippincott-Raven Publishers.