CLINICAL REVIEWSEsophageal Function Abnormalities in Patients With Barrett’s EsophagusFass, Ronnie MD, FACG*; Teramoto, Oscar MD†; Kurin, Michael MD‡; Khalessi, Ali MD§; Kitayama, Yoshitaka PhD, MD*; Shibli, Fahmi MD*Author Information *The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical System, Case Western Reserve University ‡Digestive Health Institute, University Hospitals Cleveland, OH †Gastrointestinal Department, ABC Medical Center, Mexico City, Mexico §Department of Medicine, Langone Medical Center, New York University, New York, NY The authors declare that they have nothing to disclose. Address correspondence: to Ronnie Fass, MD, FACG, Esophageal and Swallowing Center, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109 (e-mail: firstname.lastname@example.org). Journal of Clinical Gastroenterology: July 2020 - Volume 54 - Issue 6 - p 485-492 doi: 10.1097/MCG.0000000000001358 Buy Metrics Abstract Various esophageal functional abnormalities have been described in patients with Barrett’s esophagus (BE). A significantly higher esophageal acid exposure especially in the supine position has been documented in BE, as compared with the other gastroesophageal reflux disease phenotypes. In addition, weakly acidic reflux and duodenogastroesophageal reflux are more common in BE patients. The presence of Barrett’s mucosa reduces esophageal mucosal impedance, occasionally to a level that prevents detection of reflux episodes. Reduced amplitude contractions and lower esophageal sphincter basal pressure are more common in BE patients as compared with the other gastroesophageal reflux disease groups. Ineffective esophageal motility is the most commonly defined motor disorder in BE. Reduced chemoreceptor and mechanoreceptor sensitivity to acid and balloon distention, respectively, have been suggested to explain lack or significantly less reports of reflux-related symptoms by BE patients. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.