CLINICAL REVIEWSCeliac Disease Extraintestinal Manifestations and Associated ConditionsTherrien, Amelie MD, MSc*,†; Kelly, Ciaran P. MD*,†; Silvester, Jocelyn A. MD, PhD†,‡,§Author Information *Department of Medicine, Celiac Center, Division of Gastroenterology, Beth Israel Deaconess Medical Center †Celiac Research Program, Harvard Medical School ‡Division of Gastroenterology, Hepatology and Nutrition, Boston Children Hospital, Boston, MA §Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada Supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Numbers K23DK119584 and T32DK07760 awarded to J.A.S. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. A.T. was supported by the DG Kinnear Award from the Association des Gastroenterologues du Quebec and Phase 2 Award from the Fonds de Recherche Sante Quebec (Programme FRQS/MSSS de formation pour médecins résidents en médecine spécialisée visant une carrière en recherche). A.T., J.A.S., C.P.K.: conception and design. A.T.: drafting of the manuscript. J.A.S. and C.P.K.: critical review of the manuscript. All authors have approved the final draft submitted. J.A.S. has received consulting fees from Takeda Pharmaceuticals International Co., and research support from Cour Pharmaceuticals, Biomedal SL, and Glutenostics LLC. C.P.K. has acted as a scientific advisor to companies attempting to develop new diagnostic and management approaches for celiac disease including Cour Pharmaceuticals, Glutenostics, Innovate, ImmunogenX, and Takeda Pharmaceuticals. He also acts as Principal Investigator on research grants on celiac disease supported by Aptalis, and Takeda Pharmaceuticals International Co. A.T. has nothing to disclose. Address correspondence to: Jocelyn A. Silvester, MD, PhD, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Dana 637, Boston, MA 02215 (e-mail: email@example.com). Online date: September 10, 2019 Journal of Clinical Gastroenterology: January 2020 - Volume 54 - Issue 1 - p 8-21 doi: 10.1097/MCG.0000000000001267 Buy Metrics Abstract Celiac disease is a common form of enteropathy with frequent extraintestinal manifestations (EIM). Misrecognition of these presentations may lead to significant delays in diagnosis. Any organ may be involved, either through an immune/inflammatory phenomenon, or nutritional deficiencies. Some EIM, such as gluten ataxia, may be irreversible if left untreated, but most will improve with a gluten-free diet. Knowledge of the various EIM, as well as the associated conditions which do not improve on a gluten-free diet, will avoid delays in the diagnosis and management of celiac disease and associated manifestations. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.