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Oral Nano Vitamin D Supplementation Reduces Disease Activity in Ulcerative Colitis

A Double-Blind Randomized Parallel Group Placebo-controlled Trial

Ahamed Z, Rizwan MD, DM*; Dutta, Usha MD, DM, MSc*; Sharma, Vishal MD, DM*; Prasad, Kaushal Kishor MD*; Popli, Priyanka MSc*; Kalsi, Dimple MSc*; Vaishnavi, Chetana MSc, PhD*; Arora, Sunil MSc, PhD*,†; Kochhar, Rakesh MD, DM*

doi: 10.1097/MCG.0000000000001233
ONLINE ARTICLES: Original Articles

Introduction: Vitamin D possesses anti-inflammatory properties and could be beneficial in ulcerative colitis (UC).

Methods: We studied the effect of oral nano vitamin D3 supplementation on disease activity in active UC [ulcerative colitis disease activity index (UCDAI)≥3]. Patients with active UC and vitamin D <40 ng/mL were randomized to receive either oral nano vitamin D (60,000 IU/d×8 d) or placebo. They were evaluated for disease activity (UCDAI scores, C-reactive protein, erythrocyte sedimentation rate, and fecal calprotectin) at baseline and reassessed at 4 weeks. The response was defined as a 3-point reduction in UCDAI score at 4 weeks and reduction in inflammatory markers.

Results: The median vitamin D levels increased from 15.4 to 40.83 mg/dL in vitamin D group (P≤0.001) and marginally from 13.45 to 18.85 mg/dL (P=0.027) in controls. The 3-point reduction in UCDAI was seen more often in vitamin D group as compared with the control (53% vs. 13%; P=0.001). Increase in vitamin D levels correlated with reduction in UCDAI score (P≤0.001; ρ=−0.713), C-reactive protein (P≤0.001; ρ=−0.603), and calprotectin (P=0.004; ρ=−0.368). Patients who achieved target vitamin D of >40 ng/mL (n=17) more often had a 3-point reduction in UCDAI (80% vs. 20%; P≤0.001) and reduction in grade of severity from 60% to 35% (P=0.038). Vitamin D administration (odds ratio, 9.17; 95% confidence interval, 2.02-41.67) and baseline histologic activity (odds ratio, 1.92; 95% confidence intervals, 1.2-3.08) independently predicted response.

Conclusions: Oral nano vitamin D supplementation in active UC is associated with a reduction in disease activity and severity grade and is seen more often in those who achieved a target vitamin D level of 40 ng/mL.

*Department of Gastroenterology

Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

The authors declare that they have nothing to disclose.

Address correspondence to: Usha Dutta, MD, DM, MSc, Department of Gastroenterology, PGIMER, Sector-12, Chandigarh 160012, India (e-mail:

Received July 30, 2018

Accepted May 5, 2019

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