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Incidence Rate of Gastric Cancer Adenocarcinoma in Patients With Gastric Dysplasia

A Systematic Review and Meta-Analysis

Akbari, Maryam PhD*; Kardeh, Bahareh MD*; Tabrizi, Reza PhD*; Ahmadizar, Fariba PhD; Lankarani, Kamran B. MD

doi: 10.1097/MCG.0000000000001257

Several studies have reported the risk of progression to gastric adenocarcinoma (GAC) in patients with gastric dysplasia (GD); however, the findings are controversial. We performed a systematic review and meta-analysis to study the incidence rate of GAC among patients with GD. Using a comprehensive search strategy, we systematically searched online databases including PubMed, Scopus, EMBASE, Cochrane Library, and Web of Science databases for identifying all relevant original articles through inception until July 2018. Cochran Q and I2 tests were used to assess heterogeneities between included studies. The incidence rates of GAC and their corresponding 95% confidence intervals (CIs) were pooled using random-effect or fixed-effect models. Of the 1980 retrieved records, 30 eligible articles (61 studies) were included. The overall pooled incidence rate of GAC was 40.36 (95% CI, 27.08-55.71; I2, 96.0%) cases per 1000 person-years in patients with GD. Subgroup analysis according to the type of GD indicated the highest incidence rate of GAC was 186.40 (95% CI, 106.63-285.60; I2, 94.6%) per 1000 person-years among patients with high-grade dysplasia (HGD) lesions. Although the incidence rates of GAC in low-grade dysplasia (LGD) lesions and in nonclassified lesions were 11.25 (95% CI, 3.91-21.22; I2, 89.3%), and 1.40 (95% CI, 0.00-9.71; I2, 78.8%), respectively. Compared with patients with LGD lesions, progression rate from GD to GAC was roughly 16 times greater in patients with HGD lesions. As the majority of patients with GAC are diagnosed in an advanced stage our study suggests strict management of HGD lesions to prevent GAC.

*Health Policy Research Center, Institute of Health, Student Research Committee

Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, I.R. Iran

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Research reported in this publication was supported by Elite Researcher Grant Committee under award number (977169) from the National Institutes for Medical Research Development (NIMAD), Tehran, Iran.

K.B.L., M.A., B.K., and R.T.: contributed in conception, design, statistical analysis, and drafting of the manuscript. And also, F.A. contributed in conception and major revising of manuscript. The final version was confirmed by all authors for submission.

The authors declare that they have nothing to disclose.

Address correspondence to: Kamran B. Lankarani, MD, Health Policy Research Center, Institute of Health, 8th Floor, Building No. 2, School of Medicine, Zand Avenue, Shiraz, I.R. Iran (e-mail:

Online date: October 7, 2019

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