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Evaluation and Management of Premalignant Conditions of the Esophagus

A Systematic Survey of International Guidelines

Ramai, Daryl MD, MScBR*; Lai, Jonathan K. MD, MSc; Ofori, Emmanuel MD; Linn, Sandar MD; Reddy, Madhavi MD, FACG

Journal of Clinical Gastroenterology: October 2019 - Volume 53 - Issue 9 - p 627–634
doi: 10.1097/MCG.0000000000001247

Esophageal cancer represents one of the most lethal forms of malignancy. The growing incidence of esophageal adenocarcinoma represents an emerging public health concern. This review article summarizes current diagnostic, management, and therapeutic practices of premalignant conditions of the esophagus including Barrett’s esophagus, tylosis, granular cell tumors, achalasia, and the ingestion of caustic substances. Our report provides clinicians and academics with a global clinical perspective regarding presentation, surveillance guidelines, and therapeutic management of these esophageal conditions.

*Department of Medicine

Division of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, Brooklyn, New York, NY

McGill University Medical Centre, Montreal, QC, Canada

D.R.: designed and conceived the study. D.R. and J.K.L.: drafted the manuscript. S.L., J.K.L., E.O., S.L., and M.R.: edited the manuscript for intellectual content.

The authors declare that they have nothing to disclose.

Address correspondence to: Jonathan K. Lai, MD, MSc, McGill University Medical Centre, 1001 Decarie Boulevard, Montreal, QC, Canada H4A 3J1 (e-mail:

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