PRESENTATIONProbiotics in Pediatric Gastroenterology Emerging Indications in Inflammatory Bowel DiseasesScarpato, Elena MD, PhD; Russo, Marina MD; Staiano, Annamaria MDAuthor Information Department of Translational Medical Sciences, Section of Paediatrics, University Federico II of Naples, Naples, Italy A.S. has participated as a clinical investigator for Aboca and Nestlé, was/is advisory board member for Sucampo, and consultant for Aboca and D.M.G. Italy, and speaker for Angelini, Miltè, and Valeas. The remaining authors declare that they have nothing to disclose. Address correspondence to: Annamaria Staiano, MD, Department of Translational Medical Sciences, Section of Paediatrics, University Federico II of Naples, via Pansini 5, Naples 80131, Italy (e-mail: firstname.lastname@example.org). Journal of Clinical Gastroenterology: November/December 2018 - Volume 52 - Issue - p S7-S9 doi: 10.1097/MCG.0000000000001095 Buy Metrics Abstract Etiology of inflammatory bowel disease (IBD) is not yet completely understood, but it is hypothesized that a disruption of the immune tolerance to gut microbiota, due to several potential factors like an abnormal gut microbiota composition and activity, may lead to IBD occurrence. Manipulation of the intestinal microbiota is an attractive target for the management of IBD, and probiotics could be useful to influence the disease’s course. However, the existing literature on the usefulness of probiotics in IBD is relatively limited. At present, there is no evidence of efficacy for any bacterial strain in the induction or maintenance of remission in pediatric Crohn’s disease, while there is limited evidence for the use of VSL#3 and Lactobacillus reuteri ATCC 55730, in addition to standard therapy, for the induction of remission in pediatric ulcerative colitis. Moreover, current data assessing the therapeutic efficacy of probiotics in IBD do not fulfill evidence-based standards, with long-term maintenance studies and larger prospective randomized controlled trials still lacking. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.