PRESENTATIONInfluence of Probiotics Administration on Gut Microbiota Core A Review on the Effects on Appetite Control, Glucose, and Lipid MetabolismFalcinelli, Silvia PhD*; Rodiles, Ana PhD†; Hatef, Azadeh PhD‡; Picchietti, Simona PhD§; Cossignani, Lina PhD∥; Merrifield, Daniel L. PhD†; Unniappan, Suraj PhD‡; Carnevali, Oliana PhD*Author Information *Department of Life and Environmental Sciences (DiSVA), Marche Polytechnic University, Ancona §Department for Innovation in Biological, Agro-food and Forest Systems (DIBAF), University of Tuscia, Viterbo ∥Department of Economics-Estimative Science and Food, Bromatological Chemistry Division, Biochemistry, Physiology and Nutrition, University of Perugia, Perugia, Italy †Aquatic Animal Nutrition and Health Research Group, School of Biological Sciences, Plymouth University, UK ‡Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Supported by FA 2013, PRIN 2010-2011 prot 2010W87LBJ, EU COST AQUAGAMETS 2012 given to O.C. In addition, this research was partially funded by a Discovery Grant and Discovery Accelerator Supplement Award to S.U. Infrastructure for the work conducted in the laboratory of S.U. was provided by the Canada Foundation for Innovation—John Evans Leadership Fund and the Saskatchewan Health Research Foundation (SHRF) Establishment Grant. S.U. received a Canadian Institutes of Health Research (CIHR) New Investigator Award. A.H. is a recipient of postdoctoral fellowships from the CIHR and SHRF. The authors declare that they have nothing to disclose. Address correspondence to: Oliana Carnevali, PhD, Department of Life and Environmental Sciences (DiSVA), Marche Polytechnic University, Brecce Bianche 1 Street, Ancona 60131, Italy (e-mail: [email protected]). Journal of Clinical Gastroenterology: November/December 2018 - Volume 52 - Issue - p S50-S56 doi: 10.1097/MCG.0000000000001064 Buy Metrics Abstract An increasing number of studies has shown that dietary probiotics exert beneficial health effects in both humans and animals. It is well established that gut microbiota play a pivotal role in regulating host metabolism, and a growing number of studies has elucidated that probiotics positively interfere with gut microbiota. Accumulating evidence shows that probiotics, through their metabolic activity, produce metabolites that in turn contribute to positively affect host physiology. For these reasons, probiotics have shown significant potential as a therapeutic tool for a diversity of diseases, but the mechanisms through which probiotics act has not been fully elucidated yet. The goal of this review was to provide evidence on the effects of probiotics on gut microbiota changes associated with host metabolic variations, specifically focusing on feed intake and lipid and glucose metabolism. In addition, we review probiotic interaction with the gut microbiota. The information collected here will give further insight into the effects of probiotics on the gut microbiota and their action on metabolite release, energy metabolism, and appetite. This information will help to improve knowledge to find better probiotic therapeutic strategies for obesity and eating disorders. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.