CLINICAL REVIEWSIntestinal Failure Adaptation, Rehabilitation, and TransplantationBharadwaj, Shishira MD; Tandon, Parul DO; Meka, Krishna DO; Rivas, John M. MD; Jevenn, Andrea RD; Kuo, Ning-Tsu PharmD, PhD; Steiger, Ezra MD, FACSAuthor Information *Center for Gut Rehabilitation and Transplantation, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, OH †College of Osteopathic Medicine, Michigan State University, East Lansing, MI The authors declare that they have nothing to disclose. Reprints: Ezra Steiger, MD, FACS, Center for Gut Rehabilitation and Transplantation, Digestive Disease Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195 (e-mail: [email protected]). Journal of Clinical Gastroenterology: May/June 2016 - Volume 50 - Issue 5 - p 366-372 doi: 10.1097/MCG.0000000000000512 Buy Metrics Abstract Intestinal failure (IF) is a state in which the nutritional demands are not met by the gastrointestinal absorptive surface. A majority of IF cases are associated with short-bowel syndrome, which is a result of malabsorption after significant intestinal resection for numerous reasons, some of which include Crohn’s disease, vascular thrombosis, and radiation enteritis. IF can also be caused by obstruction, dysmotility, and congenital defects. Recognition and management of IF can be challenging, given the complex nature of this condition. This review discusses the management of IF with a focus on intestinal rehabilitation, parenteral nutrition, and transplantation. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.