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Preoperative Percutaneous Drainage of Spontaneous Intra-Abdominal Abscess in Patients With Crohn’s Disease

A Meta-Analysis

He, Xiaosheng MD*; Lin, Xutao MD*; Lian, Lei MD, PhD; Huang, Juanni MD*; Yao, Qiuqiong RN*; Chen, Zexian MD*; Fan, Dejun MD*; Wu, Xiaojian MD, PhD*; Lan, Ping MD, PhD*

Journal of Clinical Gastroenterology: October 2015 - Volume 49 - Issue 9 - p e82–e90
doi: 10.1097/MCG.0000000000000219
ONLINE ARTICLE: Original Article
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Goals: We aimed to compare clinical outcomes between percutaneous drainage (PD) with or without further elective surgery and initial surgery for patients with Crohn’s disease (CD)-related spontaneous intra-abdominal abscess.

Background: Intra-abdominal abscess is common in patients with CD leading to significant morbidity. The role of PD before abdominal surgery in patients with CD remains controversial.

Study: We performed a meta-analysis comparing PD and surgery as the initial approach to CD-related spontaneous intra-abdominal abscess. Overall complication and recurrent abscess were assessed. Subgroup analyses on initial PD were performed including preoperative PD and PD alone.

Results: A total of 9 studies including 513 patients with CD-related spontaneous intra-abdominal abscesses were included. The overall complication rate was significantly higher in patients undergoing initial surgery compared with those undergoing initial PD [odds ratio (OR)=0.58; 95% confidence interval (CI), 0.35-0.96; P=0.03]. In a subgroup analysis, preoperative PD was associated with a significant reduction in overall complication (OR=0.44; 95% CI, 0.23-0.83; P=0.01) as compared with initial surgery. The risk for recurrent abscess was higher in patients who underwent PD alone than those who underwent initial surgery (OR=2.16; 95% CI, 1.03-4.54; P=0.04). No significance difference in postoperative recurrent abscess was found between preoperative PD group and initial surgery group.

Conclusion: Although abdominal surgery appeared to be inevitable in the majority of the patients with CD who develop intra-abdominal abscess, preoperative PD may decrease overall complication after surgery.

*Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University

Department of Geriatric, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China

X.H., X.L., and L.L. contributed equally.

Supported by the National Natural Science Foundation of China (81200332) and the Foundation for Distinguished Young Talents in Higher Education of Guangdong, China (2012LYM_0005).

The authors declare that they have nothing to disclose.

Reprints: Ping Lan, MD, PhD, Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangzhou, Guangdong 510655, China (e-mail: sumslp@163.com).

Received May 4, 2014

Accepted August 2, 2014

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.