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Fecal Microbiota Transplantation Inducing Remission in Crohn’s Colitis and the Associated Changes in Fecal Microbial Profile

Kao, Dina MD, FRCPC*; Hotte, Naomi MSc*; Gillevet, Patrick PhD; Madsen, Karen PhD*

Journal of Clinical Gastroenterology: August 2014 - Volume 48 - Issue 7 - p 625–628
doi: 10.1097/MCG.0000000000000131
ALIMENTARY TRACT: Case Report
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Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine of unclear etiology. Increasing evidence has pointed to intestinal dysbiosis as a potential factor in a genetically susceptible individual. Fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease with variable degrees of success. Herein, we report a patient with Crohn’s colitis, previously failing an immunosuppressant, who achieved clinical, endoscopic, and histologic remission after a single fecal microbiota transplantation infusion. We have further characterized the changes in the fecal microbiota associated with this observation.

*Department of Medicine, University of Alberta, Edmonton, AB

Department of Environmental Science and Policy, George Mason University, Manassa, VA

Supported by grants from Alberta IBD Consortium; Alberta Innovates.

D.K.: study concept and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; critical revision of the manuscript for important intellectual content. N.H.: acquisition of data; analysis and interpretation of data; critical revision of the manuscript for important intellectual content. P.G.: analysis and interpretation of data; critical revision of the manuscript for important intellectual content; administrative, technical and material support. K.M.: study concept and design; analysis and interpretation of data; critical revision of the manuscript for important intellectual content; administrative, technical and material support.

The authors declare that they have nothing to disclose.

Reprints: Dina Kao, MD, FRCPC, Zeidler Ledcor Centre, 130 University Campus, University of Alberta, Edmonton, AB, T6G2X8 (e-mail: dkao@ualberta.ca).

© 2014 by Lippincott Williams & Wilkins