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Serum Thioredoxin-1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma

Tabata, Chiharu MD, PhD*†; Terada, Takayuki MD*†; Tabata, Rie MD, PhD; Yamada, Shusai MD, PhD*; Eguchi, Ryoji PhD; Fujimori, Yoshihiro MD, PhD§; Nakano, Takashi MD, PhD*†

Journal of Clinical Gastroenterology: January 2013 - Volume 47 - Issue 1 - p e7–e11
doi: 10.1097/MCG.0b013e31824e901b
ONLINE ARTICLES: Original Articles

Background: Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, diagnosing DMPM early is very important. Reactive oxygen species play an important role in asbestos toxicity, which is associated with the pathogenesis of DMPM growth. Thioredoxin-1 (TRX) is a small redox-active protein that demonstrates antioxidative activity associated with tumor growth. Here, we investigated the serum levels of TRX in patients with DMPM and compared them with those of a population that had been exposed to asbestos but did not have DMPM.

Study: The serum concentrations of TRX were measured in 15 DMPM patients and 34 individuals with benign asbestos-related diseases.

Results: We demonstrated that the patients with DMPM had significantly higher serum levels of TRX than the population that had been exposed to asbestos but did not have DMPM.

Conclusions: Our data suggest that serum TRX concentration is a useful serum marker for DMPM.

*Department of Internal Medicine, Division of Respiratory Medicine

Department of Thoracic Oncology, Hyogo College of Medicine

Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital

§Hyogo College of Medicine Cancer Center, Hyogo, Japan

C.T. and T.T. contributed equally.

C.T., R.T., and T.N.: designed research; C.T. and T.T.: performed research; C.T., T.T., R.E., and Y.F.: collected data; C.T. and R.T.: analyzed and interpreted data; C.T.: performed statistical analysis; C.T. and R.T.: wrote the manuscript.

Supported by grants from KAKENHI, a Grant-in-Aid for Scientific Research (C) (23591167) and Health Labour Sciences Research Grant.

The authors declare that they have nothing to disclose.

Reprints: Chiharu Tabata, MD, PhD, Department of Internal Medicine, Division of Respiratory Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan (e-mail:

Received November 4, 2011

Accepted February 3, 2012

© 2013 Lippincott Williams & Wilkins, Inc.