CASE REPORTSAgranulocytosis Induced by Proton Pump InhibitorsDury, Sandra MD*; Nardi, Julie MD*; Gozalo, Claire MD†; Lebargy, François MD, PhD*,‡; Deslee, Gaëtan MD, PhD*,§Author Information *Departments of Respiratory Medicine †Pharmacology and Toxicology, University Hospital of Reims ‡Immunology and Microbiology Unit §INSERM UMRS 903, University of Reims, Reims, France The authors declare that they have nothing to disclose. Reprints: Sandra Dury, MD, Department of Respiratory Medicine; Hôpital Maison Blanche—University Hospital of Reims; 45, rue de Cognacq-Jay, 51 100 Reims, France (e-mail: [email protected]). Journal of Clinical Gastroenterology: November/December 2012 - Volume 46 - Issue 10 - p 859 doi: 10.1097/MCG.0b013e318236f18a Buy Metrics Abstract We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors. © 2012 Lippincott Williams & Wilkins, Inc.