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Irritable Bowel Syndrome and Small Intestinal Bacterial Overgrowth

Yamini, David MD; Pimentel, Mark MD, FRCP(C)

Journal of Clinical Gastroenterology: November-December 2010 - Volume 44 - Issue 10 - p 672-675
doi: 10.1097/MCG.0b013e3181ef3476
ALIMENTARY TRACT: Clinical Reviews

In the last 3 decades, there has been a growing appreciation for the role of gut bacteria in gastrointestinal disease. Although inflammatory bowel disease and peptic ulcer disease have established a role for gut bacteria for more than 20 years, there is now increasing evidence that intestinal bacteria may play a role in irritable bowel syndrome as well. In this review, the current evidence for bacteria in irritable bowel syndrome will be examined.

GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, CA

Supported in part by the Beatrice and Samuel A. Seaver Foundation.

Reprints: Mark Pimentel, MD, FRCP(C), GI Motility Program Cedars-Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048 (e-mail:

Dr Mark Pimentel is a consultant for Salix Pharmaceuticals and has grant funding from Prometheus Diagnostics and Salix Pharmaceuticals. Cedars-Sinai has a licensing agreement with Salix Pharmaceuticals. Dr David Yamini has nothing to disclose.

© 2010 Lippincott Williams & Wilkins, Inc.