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Celiac Disease: Prevention and Treatment

Selimoğlu, Mukadder Ayşe MD; Karabiber, Hamza MD

Journal of Clinical Gastroenterology: January 2010 - Volume 44 - Issue 1 - p 4-8
doi: 10.1097/MCG.0b013e3181b7ead2

Celiac disease is a common multisystemic disorder that may be diagnosed at any age. Owing to the increasing prevalence, prevention strategies, including encouragement of breastfeeding and introduction of small amounts of gluten whereas still on breastfeeding at fourth to sixth month of age, become more important than before. For avoiding complications of celiac disease, a strict gluten-free diet is essential. A lifelong gluten-free diet may bring about difficulties as avoiding gluten completely is problematic owing to the contamination with gluten of presumably gluten free foods. New therapeutic approaches include enzyme supplementation, correction of the intestinal barrier defect against gluten entry, blocking of gliadin presentation by human leukocyte antigen blockers and tissue transglutaminase inhibitors.

İnönü University, Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Malatya, Turkey

Reprints: Mukadder Ayşe Selimoğlu, MD, İnönü Üniversitesi, Tıp Fakültesi, Çocuk Sağlığıve Hastalıkları AD, 44280, Malatya, Turkey (e-mail:

The authors of the manuscript, state that they do not have any conflict of interest or any financial support or affiliation with institutions, organizations, or companies that are mentioned in the manuscript or whose products or services are discussed.

© 2010 Lippincott Williams & Wilkins, Inc.