PRESENTATIONSThe Nutritional Modulation of the Evolving IntestineBerni Canani, Roberto MD, PhD; Passariello, Annalisa MD, PhD; Buccigrossi, Vittoria MD, PhD; Terrin, Gianluca MD, PhD; Guarino, Alfredo MDAuthor Information Department of Pediatrics, University Federico II of Naples, Naples, Italy Conflict of Interest Disclosure and Declaration of Funding Source: all the authors stated the absence of any conflict of interest. The research was not sponsored by any pharmaceutical or food company. Reprints: Roberto Berni Canani, MD, PhD, Department of Pediatrics, University of Naples “Federico II” Via S. Pansini, 5; Naples 80131, Italy (e mail: [email protected]). Received for publication April 21, 2008; accepted April 23, 2008 Journal of Clinical Gastroenterology: September 2008 - Volume 42 - Issue - p S197-S200 doi: 10.1097/MCG.0b013e31817da155 Buy Metrics Abstract Nutrition plays a major role in the modulation of the evolving human gut influencing all the main components of the intestinal ecosystem. The regulatory role of nutrition is particularly crucial in the early postnatal period but it continues also in subsequent ages when the development of the gastrointestinal tract is completed. Recent data support the hypothesis that nutrition can affect some inherited disorders of gastrointestinal tract. These “epigenetic” mechanisms are involved in the development of intestinal enzymes, hormones, transporters, and immunity. This is an expanding research area related to the possible nutritional intervention in selected clinical condition. This paper is focused on the main components and mechanisms of action of the nutritional modulation on intestinal development. © 2008 Lippincott Williams & Wilkins, Inc.