PRESENTATIONSProbiotic Lactobacilli for Urogenital Health in WomenReid, Gregor PhD, MBA* † Author Information *Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute †Departments of Microbiology and Immunology and Surgery, The University of Western Ontario, London, Ontario, Canada Funding Sources: Ontario Ministry of Agriculture and Food, Natural Sciences and Engineering Research Council of Canada, and the Advanced Food and Materials Network. Reprints: Gregor Reid, PhD, MBA, Canadian Research and Development Centre for Probiotics, F2-116 Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, N6A 4V2 Canada (e-mail: [email protected]). Received for publication April 23, 2008; accepted April 25, 2008 Conflicts of Interest: Dr Reid developed the use of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 for urogenital health and licensed the strains to Chr Hansen. Journal of Clinical Gastroenterology: September 2008 - Volume 42 - Issue - p S234-S236 doi: 10.1097/MCG.0b013e31817f1298 Buy Metrics Abstract The microbiota of the vagina form mostly from ascension of microbes from the rectal area. The numbers and types of microbes fluctuates with hormone levels, sexual contact, douching, and diet, yet the basic composition is relatively simple, with lactobacilli dominant in healthy females. The depletion of these organisms in women susceptible to urinary and vaginal infections, raised the question of whether artificial supplementation of lactobacilli could lower infection rates. To date, a 2 strain combination of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 have proved to be the most effective at restoring and maintaining a normal vaginal microbiota. Other organisms show promise in resolving diseases that afflict over 1 billion women worldwide each year. The mechanisms involved have not been completely resolved, but seem to include modulation of host immunity, reduction in pathogen ascension from the rectum, and interference with colonization and survival of pathogens. © 2008 Lippincott Williams & Wilkins, Inc.