ALIMENTARY TRACT: Case ReportHigh Risk of Malignancy in Familial Barrett's Esophagus Presentation of One FamilyMunitiz, Vicente MD, PhD*; Parrilla, Pascual MD, PhD*; Ortiz, Angeles MD, PhD*; Martinez-de-Haro, Luisa F. MD, PhD*; Yelamos, Jose MD*; Molina, Joaquin MD†Author Information Departments of *Surgery †Endoscopy, Virgen de la Arrixaca University Hospital, Murcia, Spain The authors declare no conflict of interest. The authors confirm that there is no financial arrangement with companies that are mentioned in the manuscript. Reprints: Vicente Munitiz, MD, Servicio de Cirugía General, 3a planta, Hospital Universitario Virgen de la Arrixaca, Ctra. Cartagena s/n, El Palmar 30120, Murcia, Spain (e-mail: [email protected]). Received for publication September 15, 2006; accepted December 22, 2006 Journal of Clinical Gastroenterology: August 2008 - Volume 42 - Issue 7 - p 806-809 doi: 10.1097/MCG.0b013e3180329015 Buy Metrics Abstract Barrett's esophagus is an acquired condition fundamentally related to the presence of severe and prolonged pathologic acid and biliary gastro-esophageal reflux. However, genetic factors may also play a role in some cases. The aim of this study is to present 3 generations of a Spanish family with the largest number of members so far reported with Barrett's esophagus or esophageal adenocarcinoma. Of the 24 members of this family studied over 3 generations, 6 patients developed esophageal adenocarcinoma, 4 Barrett's esophagus, 6 clinical symptoms of gastro-esophageal reflux disease without Barrett's esophagus, and 8 were asymptomatic. In conclusion, patients with familial Barrett's esophagus get the disease more severely with a high rate of malignancy and, therefore, the endoscopic surveillance should be closer than in cases of nonfamilial Barrett's esophagus. © 2008 Lippincott Williams & Wilkins, Inc.