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Hyper-CK-emia in Pediatric Celiac Disease: Prevalence and Clinical Importance

Selimoglu, Mukadder Ayse MD*; Ertekin, Vildan MD; Altinkaynak, Sevin MD

Journal of Clinical Gastroenterology: August 2007 - Volume 41 - Issue 7 - p 667-670
doi: 10.1097/MCG.0b013e31802cb87a
ALIMENTARY TRACT: Clinical Research

Hyper-transaminasemia (HT) is a well-known laboratory sign of celiac disease (CD); however, hyper-creatine phosphokinase (CK)-emia (HCK) is not so familiar. As there are reported cases of myopathy associated CD in the literature, we aimed to investigate serum CK levels of children with CD. Newly diagnosed 126 children were included. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and CK levels were determined. Mean age was 8.7±4.4 years (11 mo to 18 y). Of patients, 77 (61.1%) had classic form, 49 (38.9%) had atypical form. Elevated levels of AST, ALT, and CK, respectively, were found in 65 (51.6%), 45 (35.7%), and 50 (39.7%) patients. Isolated HCK was detected in 9 (7.1%) patients. AST, ALT, and CK were all elevated in 29 (23.0%) children. Mean serum AST, ALT, and CK levels were found as 56.1±53.7 U/L (11 to 403), 44.7±44.0 U/L (7 to 290), and 258.0±686.5 U/L (36 to 5956), respectively. In 95 (75.4%) children, AST/ALT value was greater than 1, and in 19 (15.1%) it was greater than 2. We found positive correlations with the level of CK and AST, and ALT (P=0.01). CK level was inversely correlated with hemoglobin and cholesterol levels (P=0.013 and 0.007). In conclusion, this is the first study, which determined elevated serum levels of CK in CD and demonstrated that HCK is as common as HT in children with CD. We emphasize that HT seen in CD is not necessarily a sign of liver injury, but may also be due to myopathy.

*Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Inonu University, Malatya

Department of Pediatrics

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Ataturk University, Erzurum, Turkey

Reprints: Mukadder Ayse Selimoglu, MD, Inonu Universitesi, Tip Fakultesi, Cocuk Sagligi ve Hastaliklari AD, Malatya, Turkey (e-mail:

Received for publication May 4, 2006; accepted October 20, 2006

© 2007 Lippincott Williams & Wilkins, Inc.