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Diversion of the Fecal Stream Resolves Ulcerative Colitis Complicating Chronic Granulomatous Disease in an Adult Patient

Villanacci, Vincenzo, MD*; Falchetti, Diego, MD; Liserre, Barbara, MD*; Soresina, Anna Rosa, MD; Plebani, Alessandro, MD; Ekema, George, MD; Bassotti, Gabrio, MD, PhD§

Journal of Clinical Gastroenterology: May-June 2007 - Volume 41 - Issue 5 - p 491-493
doi: 10.1097/01.mcg.0000212638.44735.78
Alimentary Tract: Case Report
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Chronic granulomatous disease (CGD) is a primary phagocytic disorder characterized by greatly increased susceptibility to severe bacterial and fungal infections. Patients with CGD may have gastrointestinal manifestations, commonly colitis, usually mimicking Crohn disease. We report an adult case, the second in literature, of CGD with severe colitis displaying histologic features of ulcerative colitis. The patient had a prompt improvement (continuing up to more than 5 y of follow-up) of the clinical picture after ileostomy and fecal diversion.

*2nd Department of Pathology

Department of Pediatric Surgery

Department of Pediatrics, Spedali Civili, University of Brescia, Brescia

§Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy

Reprints: Dr Vincenzo Villanacci, MD, 2nd Department of Pathology, Spedali Civili, University of Brescia, Brescia 25123, Italy (e-mail: villanacci@spedalicivili.brescia.it).

Received for publication February 6, 2006; accepted April 15, 2006

© 2007 Lippincott Williams & Wilkins, Inc.