Chronic granulomatous disease (CGD) is a primary phagocytic disorder characterized by greatly increased susceptibility to severe bacterial and fungal infections. Patients with CGD may have gastrointestinal manifestations, commonly colitis, usually mimicking Crohn disease. We report an adult case, the second in literature, of CGD with severe colitis displaying histologic features of ulcerative colitis. The patient had a prompt improvement (continuing up to more than 5 y of follow-up) of the clinical picture after ileostomy and fecal diversion.
*2nd Department of Pathology
†Department of Pediatric Surgery
‡Department of Pediatrics, Spedali Civili, University of Brescia, Brescia
§Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Reprints: Dr Vincenzo Villanacci, MD, 2nd Department of Pathology, Spedali Civili, University of Brescia, Brescia 25123, Italy (e-mail: firstname.lastname@example.org).
Received for publication February 6, 2006; accepted April 15, 2006