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Acute Renal Dysfunction in Salmonella Gastroenteritis

Janssen van Doorn, Karin MD*; Pierard, Denis MD, PhD; Spapen, Herbert MD, PhD*

Journal of Clinical Gastroenterology: November-December 2006 - Volume 40 - Issue 10 - p 910-912
doi: 10.1097/01.mcg.0000212620.20079.34
Alimentary Tract: Clinical Research

Goals To determine the incidence of renal function deterioration in adult patients with Salmonella infection.

Background Renal impairment has been described during severe Salmonella infection and is mainly due to shock, dehydration, or rhabdomyolysis. However, it is unclear whether less severe Salmonella infection also has an impact on kidney function.

Study We retrospectively reviewed over a 2-year period the data of all hospitalized adult patients with microbiologically proven gastrointestinal infection. Different biologic parameters were compared between patients infected with Salmonella and patients with other gastrointestinal infections.

Results One hundred and seven patients with positive stool cultures were identified; 44 of them had proven Salmonella infection. Renal dysfunction, defined as an increase in serum creatinine above 1.5 mg/dL in men and above 1.3 mg/dL in women, was observed in 16 (36%) patients infected by Salmonella but only in 3 (5%) comparators (P<0.0001). Hydration status and creatine kinase levels were not different in patients affected by Salmonella as compared with other pathogens. Kidney function recovered in all but 1 patient.

Conclusions Salmonella gastroenteritis in adults is frequently accompanied by renal dysfunction that is caused by mechanisms other than dehydration or rhabdomyolysis.

Departments of *Intensive Care

Microbiology, Academisch Ziekenhuis AZ-VUB, Brussels, Belgium

Reprints: Dr Karin Janssen van Doorn, MD, Intensive Care Department, AZ-VUB, Laarbeeklaan 101, B-1090 Brussels, Belgium (e-mails:;

Received for publication February 2, 2006; accepted April 10, 2006

© 2006 Lippincott Williams & Wilkins, Inc.