PresentationsThe Pathology of Diverticulosis: Classical Concepts and Mucosal Changes in DiverticulaBrian West, A. MD, FRCPath Author Information AmeriPath New York, Gastrointestinal Diagnostics, Shelton, CT Reprints: A. Brian West, MD, FRCPath, AmeriPath NY GI Diagnostics, 1 Greenwich Place, Shelton, CT 06484 (e-mail: [email protected]). Received for publication December 8, 2005; accepted December 29, 2005 Journal of Clinical Gastroenterology: August 2006 - Volume 40 - Issue - p S126-S131 doi: 10.1097/01.mcg.0000225508.90417.07 Buy Metrics Abstract Left-sided diverticular disease affects upwards of 50% of the population over the age of 60 years in western countries and is becoming more common as the population ages. Studies from the 1960s to 1980s related its occurrence to the use of low fiber diets, and to the prolonged colonic transit time and increased intraluminal pressure associated with low-volume stools. Pulsion diverticula (pseudodiverticula) emerge through the muscularis propria of the left colon at points of penetration of the vasa recta that supply the submucosa and mucosa. Cardinal features of the sigmoid colon in diverticular disease are abnormalities of the muscularis propria, including thickening and elastosis of the teniae, shortening of the bowel, and thickening and folding of the circular muscle with the development of transverse semilunar ridges between the mesenteric and antimesenteric teniae. Complications of diverticular disease such as hemorrhage, diverticulitis, peridiverticular abscess, fistula, and perforation are well recognized. © 2006 Lippincott Williams & Wilkins, Inc.