Protracted Hiccups due to Severe Erosive Esophagitis: A Case SeriesPooran, Nakechand MD; Lee, David MD; Sideridis, Kostas DOJournal of Clinical Gastroenterology: March 2006 - Volume 40 - Issue 3 - p 183-185 Alimentary Tract: Clinical Research Buy SDC Abstract Author InformationAuthors Background Hiccups although a common annoyance of life, have been linked with significant morbidity and even death. There are numerous causes of prolonged hiccups, including diseases of the gastrointestinal tract. Hiccups are reported to represent an atypical manifestation of gastroesophageal reflux disease. Cases We report 4 cases of prolonged hiccups in patients who failed to respond to initial treatment with abortive neurologic medications and who subsequently improved on proton-pump inhibitors. Endoscopic examination revealed severe reflux esophagitis. Conclusion Hiccups are an atypical manifestation and may represent a more severe course of gastroesophageal reflux disease. Division of Gastroenterology, Long Island Jewish Medical Center, New Hyde Park, New York, NY Reprints: Nakechand Pooran, MD, Division of Gastroenterology, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040 (e-mail: firstname.lastname@example.org). Received for publication June 14, 2005; accepted August 8, 2005 Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.