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Prognostic Values of IL-6, IL-8, and IL-10 in Acute Pancreatitis

Štimac, Davor MD, PhD; Fišić, Elizabeta MSc; Milić, Sandra MD, PhD; Bilić-Zulle, Lidija MSc; Perić, Relja MD

Journal of Clinical Gastroenterology: March 2006 - Volume 40 - Issue 3 - p 209-212
Liver, Pancreas, and Biliary Tract: Clinical Research

Goals The prognostic importance of interleukin-6 (IL-6), IL-8, and IL-10 in the prediction of acute pancreatitis severity.

Background Early assessment of severity in acute pancreatitis could help the patients who are at risk of developing complications. Unfortunately, the used prognostic scoring systems generally are only moderately accurate in assessing disease severity.

Study We studied 117 consecutive patients with a diagnosis of acute pancreatitis admitted to our hospital during the past 2 years. Laboratory parameters and cytokines were analyzed from serum taken routinely on admission. Severity criteria were noted for each patient using Ranson, Glasgow, and APACHE II scoring systems. Local and systemic complications, developed during a follow-up period, were classified by Atlanta criteria.

Results IL-6 was the only parameter that statistically significantly predicted complicated acute pancreatitis (P<0.05). IL-8 and IL-10 and the 3 prognostic scoring systems used did not properly assess complicated versus noncomplicated acute pancreatitis.

Conclusions Our prospective study supported the potential importance of IL-6 in the early assessment of complicated acute pancreatitis, but also suggested that pancreatitis classified as complicated in a large number of patients could not be correctly predicted with the Ranson, Glasgow, and APACHE II scoring systems.

*Division of Gastroenterology, Department of Internal Medicine

Department for Laboratory diagnostics, Clinical Hospital Center Rijeka, Rijeka, Croatia

Reprints: Davor Štimac, MD, PhD, Division of Gastroenterology, Department of Internal Medicine, Clinical Hospital Center Rijeka, Krešimirova 42 51 000 Rijeka, Croatia (e-mail:

Received for publication May 25, 2005; accepted November 16, 2005

Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.