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Squamous Cell Carcinoma of the Pancreas

Brown, Hilary A MD*; Dotto, Jorge MD; Robert, Marie MD; Salem, Ronald R MD*

Journal of Clinical Gastroenterology: November-December 2005 - Volume 39 - Issue 10 - p 915-919
doi: 10.1097/01.mcg.0000180636.74387.e6
Liver, Pancreas, and Biliary Tract: Case Report

Squamous cell carcinoma of the pancreas is a rare condition. The incidence has been estimated at approximately 1% of all pancreatic malignancies. The histogenesis is uncertain, but it has been proposed to originate from areas of squamous metaplasia of pancreatic ductal epithelium. We present a case of a 56-year-old man who presented with back pain and was found to have a squamous cell carcinoma of the pancreas without evidence of metastatic disease. Three months after en bloc resection with negative margins and lymph nodes, he presented with widely metastatic disease. A review of the literature on the topic is presented, and the poor prognosis of this rare tumor, despite complete surgical resection, is discussed.

From the Departments of *Surgical Oncology and †Pathology, Yale University School of Medicine, New Haven, CT.

Received for publication December 9, 2004; accepted June 1, 2005.

Reprints: Ronald R. Salem, MD, Department of Surgery, School of Medicine, 333 Cedar Street, Tompkins 202, P.O. Box 208062, New Haven, CT 06520-8062 (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.