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A Randomized Formula Controlled Trial of Bifidobacterium lactis and Streptococcus thermophilus for Prevention of Antibiotic-Associated Diarrhea in Infants

Corrêa, Naflesia B. O MD*; Péret Filho, Luciano A MD, PhD*; Penna, Francisco J MD, PhD*; Lima, Fátima M. L. S MD; Nicoli, Jacques R PhD

Journal of Clinical Gastroenterology: May-June 2005 - Volume 39 - Issue 5 - p 385-389
doi: 10.1097/01.mcg.0000159217.47419.5b
Alimentary Tract: Clinical Research

Goals: This clinical trial was carried out to determine whether oral treatment with a commercial probiotic formula containing Bifidobacterium lactis and Streptococcus thermophilus would reduce the frequency of antibiotic-associated diarrhea (AAD) in infants.

Study: In this double-bind formula controlled study, 80 infants, 6 to 36 months of age, were randomly assigned to receive a commercial formula containing 107 viable cells of B. lactis and 106viable cells of S. thermophilus at the initiation of antibiotics for a duration of 15 days. The infants were assessed daily for formula intake, stool frequency, and stool consistency for a total duration of 30 days. Seventy-seven infants received nonsupplemented formula for the entire duration.

Results: There was a significant difference in the incidence of AAD in the children receiving probiotic-supplemented formula (16%) than nonsupplemented formula (31%).

Conclusions: The present study shows that prevention against AAD in infants was obtained by oral treatment with daily dose of B. lactis and S. thermophilus.

From *Departamento de Pediatria, Faculdade de Medicina, and ‡Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais; and †Departamento de Pediatria e Puericultura, Universidade Federal de Goiás, Goiânia, Brazil.

Received for publication June 8, 2004; accepted September 7, 2004.

Supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brasília, DF, Brazil, and Nestlé Brasil Ltda, São Paulo, Brazil.

Reprints: Jacques R. Nicoli, PhD, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, C.P. 486, 30161-970, Belo Horizonte, Minas Gerais, Brazil (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.