Rofecoxib and Inflammatory Bowel Disease: Clinical and Pathologic ObservationsWilcox, Gilbert M MD*; Mattia, Anthony R MD†Journal of Clinical Gastroenterology: February 2005 - Volume 39 - Issue 2 - p 142-143 doi: 10.1097/01.mcg.0000150243.72499.6b Alimentary Tract: Case Report Buy SDC Abstract Author InformationAuthors Article MetricsMetrics Objectives: To describe clinical and pathologic findings in patients noted to develop lower gastrointestinal symptoms when exposed to rofecoxib. Methods: Case reports and associated biopsy findings. Results: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings. Two episodes were incident cases (no prior IBD); one episode was recurrent colitis or a nonincident case (flare of prior IBD). All symptoms resolved with drug withdrawal. Conclusions: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib. Abnormalities resolve with drug withdrawal. From the Departments of *Gastroenterology and †Pathology, Maine Medical Center, Portland, ME. Recevied for publication April 27, 2004; accepted June 2, 2004 Reprints: Gilbert M. Wilcox, MD, Maine Gastroenterology Associates, 131 Chadwick Street, Portland, ME 04102-3214 (e-mail: firstname.lastname@example.org). © 2005 Lippincott Williams & Wilkins, Inc.