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New Scientific Paradigms for Probiotics and Prebiotics

Reid, Gregor PhD; Sanders, M. E. PhD; Gaskins, H. Rex PhD; Gibson, Glenn R. PhD; Mercenier, Annick PhD; Rastall, Robert PhD; Roberfroid, Marcel PhD; Rowland, Ian PhD; Cherbut, Christine PhD; Klaenhammer, Todd R. PhD

Journal of Clinical Gastroenterology: August 2003 - Volume 37 - Issue 2 - p 105-118
Consensus Report

The inaugural meeting of the International Scientific Association for Probiotics and Prebiotics (ISAPP) was held May 3 to May 5 2002 in London, Ontario, Canada. A group of 63 academic and industrial scientists from around the world convened to discuss current issues in the science of probiotics and prebiotics. ISAPP is a non-profit organization comprised of international scientists whose intent is to strongly support and improve the levels of scientific integrity and due diligence associated with the study, use, and application of probiotics and prebiotics. In addition, ISAPP values its role in facilitating communication with the public and healthcare providers and among scientists in related fields on all topics pertinent to probiotics and prebiotics. It is anticipated that such efforts will lead to development of approaches and products that are optimally designed for the improvement of human and animal health and well being. This article is a summary of the discussions, conclusions, and recommendations made by 8 working groups convened during the first ISAPP workshop focusing on the topics of: definitions, intestinal flora, extra-intestinal sites, immune function, intestinal disease, cancer, genetics and genomics, and second generation prebiotics.

From the Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute (G.R.); University of Western Ontario, London, Canada (G.R.); Dairy and Food Culture Technologies, Centennial, CO (M.E.S.); University of Illinois, Urbana, IL (H.R.G.); University of Reading, UK (G.R.G., R.R.); Institut Pasteur de Lille, Lille, France (A.M.); Universite Catholique Louvain, Belgium (M.R.); University of Ulster, Northern Ireland (I.R.); National Institute for Agricultural Research, Nantes, France (C.C.); and North Carolina State University, Raleigh, NC. (T.R.K.)

Submitted February 19, 2003.

Accepted March 25, 2003

Dr. Sanders is a consultant for companies interested in probiotics and prebiotics; Drs. Rowland and Roberfroid also work with industries in this field; Dr. Reid owns patents on probiotic strains; Dr. Mercenier is employed by Nestlé who produce probiotics.

Address correspondence and reprint requests to Dr. Gregor Reid, Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada. E-mail:

© 2003 Lippincott Williams & Wilkins, Inc.