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Collagenous Sprue Associated with an Extensive T-cell Lymphoma

Freeman, Hugh J. M.D.

Journal of Clinical Gastroenterology: February 2003 - Volume 36 - Issue 2 - p 144-146
Alimentary Tract: Case Reports

A 79-year-old woman developed collagenous sprue, a rare small intestinal mucosal disorder. Later, extensive T-cell lymphoma was documented, a neoplasm known to complicate celiac disease. Although the precise relationship of collagenous sprue to celiac disease has been debated and remains controversial, the findings here provide additional evidence that collagenous sprue and celiac disease are closely linked. In the past, long-term survival with collagenous sprue may have been compromised due to severe pan-malabsorption. With improved treatment measures, including modern nutritional support, it is likely that there will be an increased opportunity in future for improved appreciation of the complications of collagenous sprue, specifically, lymphoma.

From the Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC.

Submitted February 28, 2002.

Accepted May 14, 2002.

Address correspondence and reprint requests to Dr. Hugh Freeman, ACU M-421, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5.

© 2003 Lippincott Williams & Wilkins, Inc.