Saccharomyces boulardii is widely used as a probiotic compound. Clinical data suggest that this agent is safe and effective. We report two cases of fungemia caused by S. cerevisiae occurring in immunosuppressed patients treated orally with S. boulardii. Molecular typing confirmed clonality in isolate strains from patients and the S. boulardii capsule. Physicians caring for immunosuppressed patients must be aware of this potential serious complication of probiotic use.
From the Departments of Internal Medicine (M.A.C., C.P., J.A.L.) and Gastroenterology (A.J.R., M.A.), and the Clinical Microbiology Laboratory (A.M.G., M.S.D., P.G.), Universidad Católica de Chile, School of Medicine, Santiago, Chile.
Submitted April 4, 2002.
Accepted June 4, 2002.
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