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Saccharomyces cerevisiae Fungemia After Saccharomyces boulardii Treatment in Immunocompromised Patients

Riquelme, Arnoldo J. M.D.; Calvo, Mario A. M.D.; Guzmán, Ana M. M.D.; Depix, María S.; García, Patricia M.D.; Pérez, Carlos M.D.; Arrese, Marco M.D.; Labarca, Jaime A. M.D.

Journal of Clinical Gastroenterology: January 2003 - Volume 36 - Issue 1 - p 41-43
Alimentary Tract: Case Reports

Saccharomyces boulardii is widely used as a probiotic compound. Clinical data suggest that this agent is safe and effective. We report two cases of fungemia caused by S. cerevisiae occurring in immunosuppressed patients treated orally with S. boulardii. Molecular typing confirmed clonality in isolate strains from patients and the S. boulardii capsule. Physicians caring for immunosuppressed patients must be aware of this potential serious complication of probiotic use.

From the Departments of Internal Medicine (M.A.C., C.P., J.A.L.) and Gastroenterology (A.J.R., M.A.), and the Clinical Microbiology Laboratory (A.M.G., M.S.D., P.G.), Universidad Católica de Chile, School of Medicine, Santiago, Chile.

Submitted April 4, 2002.

Accepted June 4, 2002.

Address correspondence and reprint requests to Dr. Jaime Labarca, Department of Medicine, Pontificia Universidad Católica de Chile School of Medicine, Marcoleta #357, PO Box Casilla 114-D, Santiago, Chile. E-mail:

© 2003 Lippincott Williams & Wilkins, Inc.