Yale University Workshop on Irritable Bowel Syndrome: Clinical AspectsIrritable Bowel Syndrome: Basis of Clinical Management StrategiesRosemore, J. G. D.O.; Lacy, Brian E. M.D., Ph.D.Section Editor(s): Wald, Arnold; Modlin, Irvin M.; Floch, Martin H. Author Information Marvin M. Schuster Center for Digestive and Motility Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A. Address correspondence and reprint requests to Brian E. Lacy, Ph.D., M.D., Marvin M. Schuster Center for Digestive and Motility Disorders, Building A5-E, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224. E-mail: [email protected] Acknowledgment: The authors thank Ms. Brenda Raymond for her expert technical assistance in the preparation of this manuscript. Journal of Clinical Gastroenterology: July 2002 - Volume 35 - Issue 1 - p S37-S44 Buy Abstract Patients with irritable bowel syndrome (IBS) are often described as challenging. The diagnosis of IBS can safely be made using the Rome II criteria in conjunction with a thorough physical examination and a limited number of diagnostic studies. Although the diagnosis is generally made with a high degree of accuracy, the pathophysiology of IBS remains elusive, and treatment can be frustrating for both patient and physician alike. Important areas of research focus on the psychology of IBS, visceral hypersensitivity, motility abnormalities (e.g., heightened gastrocolonic response), and the “brain-gut axis.” A multidisciplinary effort is often required to ameliorate symptoms and improve the patients' quality of life. This review article will discuss the myriad of treatments available for patients with IBS, and provide both a clinical and practical discussion of their use, providing evidence where available and clinical experience where it is not. © 2002 Lippincott Williams & Wilkins, Inc.