Clinical ResearchLong-term Prognosis of Cirrhosis After Spontaneous Bacterial Peritonitis Treated With CeftriaxoneFrança, Alex Vianey Callado M.D.; De Souza, Juliana Bragança M.D.; Silva, Cleide Moreira B.Sc.; Soares, Elza Cotrim M.D.Author Information From the Hepatology Unit, Department of Medicine, University of Campinas, Brazil. Submitted December 13, 2000. Accepted April 2, 2001. Address correspondence and reprint requests to Dr. Alex Vianey Callado França, Disciplina de Gastroenterologia Departamento de Clínica Médica, FMRP-USP, Av. Bandeirantes, 3900, Monte Alegre Ribeirão Preto, SP, Brazil. E-mail: [email protected] Journal of Clinical Gastroenterology: October 2001 - Volume 33 - Issue 4 - p 295-298 Buy SDC Abstract Spontaneous bacterial peritonitis (SBP) is a frequent infection in cirrhotic patients with ascites, with a poor prognosis. The aims of this study were to determine the long-term survival of cirrhotic patients with SBP treated with ceftriaxone and to identify predictive factors related to survival. We studied 47 first episodes of SBP treated with ceftriaxone with a mean follow-up of 272 days. Nineteen variables were recorded to evaluate their relation to survival. The most frequent organism that caused SBP was Escherichia coli (40%). Spontaneous bacterial peritonitis resolution was achieved in 67% of patients. After resolution, SBP recurrence was observed in 44% of patients. The cumulative probability of survival was 68.1% at 1 month and 30.8% at 6 months. After uni-and multivariate analyses of all cases, SBP resolution (p = 0.0001) and international normalized ratio (INR) (p = 0.0057) were found to be related to survival. Another analysis performed after SBP resolution and SBP recurrence showed that ascitic fluid–positive culture (p = 0.0344) and INR (p = 0.0218) had statistical significance as variables predictive of long-term survival. We conclude that the survival of cirrhotic patients is very short after the first episode of SBP, a fact probably related to advanced liver disease, as liver dysfunction (INR) is the most important factor related to long-term patient survival. © 2001 Lippincott Williams & Wilkins, Inc.