Case ReportsHyperbaric Oxygen Therapy for Severe Ulcerative ColitisBuchman, Alan L. M.D., M.S.P.H.; Fife, Caroline M.D.; Torres, Carlos M.D.; Smith, Latisha M.D.; Aristizibal, Jaime M.D.Author Information From the Division of Gastroenterology and Hepatology, Northwestern University Medical School, Chicago, Illinois, U.S.A. (A.L.B.); and the Departments of Anesthesiology (C.F., L.S., J.A.) and Pathology (C.T.), University of Texas Houston Medical School and the Wound Care Center/Hermann Hospital, Houston, Texas, U.S.A. Submitted June 28, 2000. Accepted November 13, 2000. Address correspondence and reprint requests to Dr. Alan Buchman, Division of Gastroenterology and Hepatology, Northwestern University Medical School, 676 North St. Clair Street, Suite 880, Chicago, IL 60611, U.S.A. E-mail: [email protected] Journal of Clinical Gastroenterology: October 2001 - Volume 33 - Issue 4 - p 337-339 Buy SDC Abstract Hyperbaric oxygen therapy has been used to successfully treat perineal Crohn's disease. We describe the first successful use of hyperbaric oxygen therapy in the treatment of ulcerative colitis, refractory to conventional therapies. Therapy consisted of 30 courses of 100% oxygen at a pressure of 2.0 atm absolute. Clinical remission was achieved on the basis of the Truelove–Witts and disease activity index scores. Corticosteroids were successfully tapered off once remission was achieved. © 2001 Lippincott Williams & Wilkins, Inc.