Case ReportsGastric Adenocarcinoma with a Yolk Sac Component A Case Report and Review of the LiteratureWang, Lina M.D.; Tabbarah, Hassan J. M.D.; Gulati, Priya M.D.; Rice, Susan M.D.; French, Samuel W. M.D. Author Information From the Department of Pathology (L.W., P.G., S.W.F.), the Department of Medicine (H.J.T.), and the Department of Radiology (S.R.), University of California at Los Angeles-Harbor Medical Center, Torrance, California, U.S.A. Submitted February 17, 1999. Accepted June 1, 1999. Address correspondence and reprint requests to Dr. Samuel W. French, Department of Pathology, Box 12, 1000 W. Carson St, Torrance, CA 90509, U.S.A. Journal of Clinical Gastroenterology: July 2000 - Volume 31 - Issue 1 - p 85-88 Buy Abstract Gastric yolk sac tumors (YST) are very rare and are mainly reported in elderly people. We present a case of a 36-year-old man with a poorly differentiated gastric cancer showing a mixture of adenocarcinoma and yolk sac tumor that metastasized to Virchow's node. Both biopsies, Virchow's node and gastric tumor, contained areas of adenocarcinoma and yolk sac tumor that stained strongly positive for alpha fetoprotein (AFP) by the immunohistochemistry method. A high level of serum AFP (38,200 ng/mL) was also noted in this case. The response to chemotherapy in this case of mixed gastric yolk sac tumor and adenocarcinoma was not as favorable as would be expected in a pure primary germ cell tumor. © 2000 Lippincott Williams & Wilkins, Inc.