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Acalculous Acute Cholecystitis in Leukemia

Büyükaşik, Yahya M.D.; Koşar, Ali M.D.; Demiroğlu, Halûk M.D.; Altnok, Gülçin M.D.ı; Özcebe, Osman İlhami M.D.; Dündar, Semra M.D.

Journal of Clinical Gastroenterology: September 1998 - Volume 27 - Issue 2 - p 146-148
Clinical Research

Acalculous acute cholecystitis(AAC) is a well-known complication in critically ill patients. However, there is no satisfactory data regarding this complication in leukemic patients. We reviewed the medical records of 426 patients with acute or chronic leukemia retrospectively to investigate the incidence, possible pathogenetic mechanisms, and clinical course of AAC in leukemia. Six cases of AAC were identified. The incidence was 1.65% (5/302) for acute leukemias. Three out of 6 patients underwent cholecystectomy, and two recovered completely. Percutaneous cholecystostomy was performed in another patient successfully. Careful histological examinations of the surgical specimens did not reveal any specific etiopathogenetic finding. However, clinical data suggested that infectious agents and visceral ischemia may contribute to the pathogenesis of AAC in leukemia.

From the Departments of Internal Medicine (Y.B., A.K., H.D., O.İ.Ö., and S.D.) and Pathology (G.A.), Hacettepe University Medical School, Ankara, Turkey.

Address correspondence and reprint requests to Dr. Yahya Büyükaşik, Sergenler Sok. 8/15 lç Cebeci 06590 Ankara/Turkey; e-mail:

© 1998 Lippincott Williams & Wilkins, Inc.