Original StudiesClinicopathologic Features of Resected Primary Adenosquamous Carcinomas of the LiverIsa, Tsutomu M.D.; Kusano, Toshiomi M.D.; Muto, Yoshihiro M.D.; Furukawa, Masato M.D.; Kiyuna, Masaya M.D.; Toda, Takayoshi M.D.Author Information From the First Department of Surgery (T.I., T.K., Y.M.) and Clinical Laboratory Medicine (M.K., T.T.), Ryukyu University School of Medicine, Uehara, Nishihara-cho, Okinawa, and the Department of Surgery (M.F.), Nagasaki Chuo National Hospital, Kubara, Ohmura-City, Nagasaki, Japan. Received April 28, 1997. Sent for revision May 19, 1997. Accepted June 28, 1997. Address correspondence and reprint requests to Dr. Tsutomu Isa, First Department of Surgery, Ryukyu University School of Medicine, 207 Uehara, Nishihara-cho, Okinawa, 903-01 Japan. Journal of Clinical Gastroenterology: December 1997 - Volume 25 - Issue 4 - p 623-627 Buy Abstract Four cases of resected adenosquamous carcinoma of the liver were clinicopathologically reviewed, together with immunohistochemical findings. Although no lymph node metastases were seen and a curative resection was achieved in all cases, two patients had recurrences in the peritoneum and distant organs such as the pericardium and pleura relatively soon after the operation. Of the remaining two cases, one patient died during the postoperative period and the other died of coexistent hilar cholangiocarcinoma. Together these findings suggest that this disease tends to spread locally and distantly in the early phase of tumor growth and shows aggressive biological behavior. In an immunohistochemical study, involucrin was a specific marker for the squamous component and CA19-9 was a marker for the adenomatous component. © Lippincott-Raven Publishers.