Begos Dennis G. M.D; Kuan, Shihfan M.D.; Dobbins, John M.D, and; Ravikumar, Thanjavur S. M.D.Journal of Clinical Gastroenterology: April 1995 Case Studies: PDF Only Buy Abstract Celiac sprue, or nontropical sprue, is associated with an increased incidence of digestive tract malignancy. We report a patient with celiac sprue who developed two primary adenocarcinomas of the jejunum > 2 years apart. The second cancer was asymptomatic and detected by surveillance computed tomography. Small-bowel cancers are unusual, and frequency of follow-up has not been established, so that it is important to have a high index of suspicion for these malignancies in celiac patients with vague gastrointestinal symptoms. © Lippincott-Raven Publishers.