Davis George E. M.D.; O'Rourke, Marsha C. M.D.; Metz, Joseph R. M.D.; Kindig, Warren V. M.D.; Sweeney, James G. M.D.; Kane, Kevin N. M.D.Journal of Clinical Gastroenterology: August 1991 Article: PDF Only Buy Abstract We describe a 33-year-old man with giant hypertrophic gastropathy (Menetrier's disease), which, on operative biopsy of the stomach, showed a significant inflammatory component. The patient was treated with prednisone and quickly responded. Although a review of the literature revealed only two cases similarly treated, with equivocal results, spontaneous remission, does occur. Symptoms associated with this disease may respond to corticoste-roids, which may offer effective therapy while awaiting involution of the gastropathy. Thus total gastrectomy may be avoided. © Lippincott-Raven Publishers.