Langman M J S B.SC M.D. F.R.C.P.Journal of Clinical Gastroenterology: July 1987 Famotidine: An Evolution in H2 Antagonist Therapy: PDF Only Buy Abstract The large-scale use of drug treatment attests to its general value. In Western countries the general problems engendered in treating an increasingly elderly population seem likely to make drug treatment more popular. More potent treatments seem unlikely to bring significant attendant risks, but could improve, in particular, the management of gastrointestinal bleeding and of gastro-oesophageal reflux. Nonantisecretory treatments do not seem as yet to have any advantages, and there is no material evidence to suggest that long-term treatment with antisecretory agents is harmful. © Lippincott-Raven Publishers.