The Office of Science and Engineering Laboratories (OSEL) is the laboratory of the Food and Drug Administration's (FDA's) Center for Devices and Radiological Health (CDRH). As medical devices become increasingly complex, a fundamental understanding of the physical, chemical, and biological phenomena inherent in medical device interactions is crucial. The Office of Science and Engineering Laboratories strives to understand these mechanistic interactions, which manifest in a broad range of collaborative research and outreach programs. With the rapid evolution of technology utilized in medical devices, the FDA must remain on the cutting edge to make appropriately informed regulatory decisions regarding device clearance, approval, and postmarket concerns. The Office of Science and Engineering Laboratories plays a crucial role in providing a technical science and engineering knowledge base for CDRH through efforts that correspond to trends in academia and industry.