The misconnection of tubes and catheters is a serious, frequent, and underreported issue. Organizations including the Food and Drug Administration, the Joint Commission, and the ECRI Institute have made suggestions for the mitigation of misconnections. Sources of potential improvements lie with medical device manufacturers, health facilities, and healthcare workers themselves. Proposed solutions for the misconnection issue include the purchasing of non-interconnectable devices, labeling and color coding of tubes and catheters, device modification to include cross-connection resistance, and adequate education of healthcare workers on misconnection hazards and their prevention. Despite these devices being disposables, clinical engineering has a potentially important role here in its role of recognizing hazards, selecting appropriate devices, and training clinical personnel.