Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values : Journal of Computer Assisted Tomography

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Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography

Theory, Procedure, and Normal Values

Frackowiak, Richard S. J.; Lenzi, Gian-Luigi; Jones, Terry; Heather, Jon D.

Author Information

From the MRC Cyclotron Unit and Department of Medicine (Neurology), Hammersmith Hospital, London, England (R. S. J. Frackowiak, T. Jones, and J. D. Heather), and III Neurological Clinic, University of Rome, Rome, Italy. Address correspondence and reprint requests to Dr. Frackowiak at MRC Cyclotron Unit. Hammersmith Hospital, London W12, England.

Journal of Computer Assisted Tomography 4(6):p 727-736, December 1980.

Abstract

A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man noninvasivey, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.

© Lippincott-Raven Publishers.

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