Musculoskeletal ImagingT2-Weighted Dixon Turbo Spin Echo for Accelerated Simultaneous Grading of Whole-Body Skeletal Muscle Fat Infiltration and Edema in Patients With Neuromuscular DiseasesSchlaeger, Sarah*†; Klupp, Elisabeth MD*; Weidlich, Dominik MSc†; Cervantes, Barbara MSc†; Foreman, Sarah C.*; Deschauer, Marcus MD‡; Schoser, Benedikt MD§; Katemann, Christoph∥; Kooijman, Hendrik PhD∥; Rummeny, Ernst J. MD†; Zimmer, Claus MD*; Kirschke, Jan S. PD*; Karampinos, Dimitrios C. PD†Author Information From the Departments of *Diagnostic and Interventional Neuroradiology, †Diagnostic and Interventional Radiology, and ‡Neurology, Technical University of Munich; §Friedrich-Baur-Institut, Ludwig Maximilian University, Munich; and ∥Philips Healthcare, Hamburg, Germany. Received for publication October 2, 2017; accepted December 26, 2017. Correspondence to: Sarah Schlaeger, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany (e-mail: firstname.lastname@example.org). S.S and E.K. contributed equally to this work. The authors declare no conflict of interest. Journal of Computer Assisted Tomography: 7/8 2018 - Volume 42 - Issue 4 - p 574-579 doi: 10.1097/RCT.0000000000000723 Buy Metrics Abstract Objective The assessment of fatty infiltration and edema in the musculature of patients with neuromuscular diseases (NMDs) typically requires the separate performance of T1-weighted and fat-suppressed T2-weighted sequences. T2-weighted Dixon turbo spin echo (TSE) enables the generation of T2-weighted fat- and water-separated images, which can be used to assess both pathologies simultaneously. The present study examines the diagnostic performance of T2-weighted Dixon TSE compared with the standard sequences in 10 patients with NMDs and 10 healthy subjects. Methods Whole-body magnetic resonance imaging was performed including T1-weighted Dixon fast field echo, T2-weighted short-tau inversion recovery, and T2-weighted Dixon TSE. Fatty infiltration and intramuscular edema were rated by 2 radiologists using visual semiquantitative rating scales. To assess intermethod and interrater agreement, weighted Cohen's κ coefficients were calculated. Results The ratings of fatty infiltration showed high intermethod and high interrater agreement (T1-weighted Dixon fast field echo vs T2-weighted Dixon TSE fat image). The evaluation of edematous changes showed high intermethod and good interrater agreement (T2-weighted short-tau inversion recovery vs T2-weighted Dixon TSE water image). Conclusions T2-weighted Dixon TSE imaging is an alternative for accelerated simultaneous grading of whole-body skeletal muscle fat infiltration and edema in patients with NMDs. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.