The assessment of fatty infiltration and edema in the musculature of patients with neuromuscular diseases (NMDs) typically requires the separate performance of T1-weighted and fat-suppressed T2-weighted sequences. T2-weighted Dixon turbo spin echo (TSE) enables the generation of T2-weighted fat- and water-separated images, which can be used to assess both pathologies simultaneously. The present study examines the diagnostic performance of T2-weighted Dixon TSE compared with the standard sequences in 10 patients with NMDs and 10 healthy subjects.
Whole-body magnetic resonance imaging was performed including T1-weighted Dixon fast field echo, T2-weighted short-tau inversion recovery, and T2-weighted Dixon TSE. Fatty infiltration and intramuscular edema were rated by 2 radiologists using visual semiquantitative rating scales. To assess intermethod and interrater agreement, weighted Cohen's κ coefficients were calculated.
The ratings of fatty infiltration showed high intermethod and high interrater agreement (T1-weighted Dixon fast field echo vs T2-weighted Dixon TSE fat image). The evaluation of edematous changes showed high intermethod and good interrater agreement (T2-weighted short-tau inversion recovery vs T2-weighted Dixon TSE water image).
T2-weighted Dixon TSE imaging is an alternative for accelerated simultaneous grading of whole-body skeletal muscle fat infiltration and edema in patients with NMDs.
From the Departments of *Diagnostic and Interventional Neuroradiology, †Diagnostic and Interventional Radiology, and ‡Neurology, Technical University of Munich; §Friedrich-Baur-Institut, Ludwig Maximilian University, Munich; and ∥Philips Healthcare, Hamburg, Germany.
Received for publication October 2, 2017; accepted December 26, 2017.
Correspondence to: Sarah Schlaeger, Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Ismaninger Str 22, 81675 Munich, Germany (e-mail: firstname.lastname@example.org).
S.S and E.K. contributed equally to this work.
The authors declare no conflict of interest.